Late Relapse and Reinfection in HCV Patients Treated with Direct-Acting Antiviral (DAA) Drugs

Abstract

The risk of hepatitis C virus (HCV) recurrence after direct-acting antiviral (DAA) treatment is Z-score of <2.58 confirmed that viral quasispecies detected at T0 and T1 were closely related for both Pt1 and Pt2, while the Z-score for Pt4 was suggestive of possible reinfection. NGS data analyses indicate that the Z-score may be a useful parameter for distinguishing late relapse from reinfection.

Keywords

• hepatitis C virus
• HCV
• HCV reinfection
• HCV late relapse
• next-generation sequencing
• NGS