Transplant oncology – Current indications and strategies to advance the fieldKey points

Felix J. Krendl; Ruben Bellotti; Gonzalo Sapisochin; Benedikt Schaefer; Herbert Tilg; Stefan Scheidl; Christian Margreiter; Stefan Schneeberger; Rupert Oberhuber; Manuel Maglione

JHEP Reports (Feb 2024)

Transplant oncology – Current indications and strategies to advance the fieldKey points

Felix J. Krendl,
Ruben Bellotti,
Gonzalo Sapisochin,
Benedikt Schaefer,
Herbert Tilg,
Stefan Scheidl,
Christian Margreiter,
Stefan Schneeberger,
Rupert Oberhuber,
Manuel Maglione

Affiliations

Felix J. Krendl: Department of Visceral, Transplant and Thoracic Surgery, Center for Operative Medicine, Medical University of Innsbruck, Austria
Ruben Bellotti: Department of Visceral, Transplant and Thoracic Surgery, Center for Operative Medicine, Medical University of Innsbruck, Austria
Gonzalo Sapisochin: Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada
Benedikt Schaefer: Department of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Austria
Herbert Tilg: Department of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Austria
Stefan Scheidl: Department of Visceral, Transplant and Thoracic Surgery, Center for Operative Medicine, Medical University of Innsbruck, Austria
Christian Margreiter: Department of Visceral, Transplant and Thoracic Surgery, Center for Operative Medicine, Medical University of Innsbruck, Austria
Stefan Schneeberger: Department of Visceral, Transplant and Thoracic Surgery, Center for Operative Medicine, Medical University of Innsbruck, Austria
Rupert Oberhuber: Department of Visceral, Transplant and Thoracic Surgery, Center for Operative Medicine, Medical University of Innsbruck, Austria; Corresponding authors. Address: Medical University of Innsbruck, Anichstraße 35, A-6020 Innsbruck, Austria; Tel.: +43 50 504 22601, fax: +43 50 504 22601.
Manuel Maglione: Department of Visceral, Transplant and Thoracic Surgery, Center for Operative Medicine, Medical University of Innsbruck, Austria; Corresponding authors. Address: Medical University of Innsbruck, Anichstraße 35, A-6020 Innsbruck, Austria; Tel.: +43 50 504 22601, fax: +43 50 504 22601.

Journal volume & issue: Vol. 6, no. 2
p. 100965

Abstract

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Summary: Liver transplantation (LT) was originally described by Starzl as a promising strategy to treat primary malignancies of the liver. Confronted with high recurrence rates, indications drifted towards non-oncologic liver diseases with LT finally evolving from a high-risk surgery to an almost routine surgical procedure. Continuously improving outcomes following LT and evolving oncological treatment strategies have driven renewed interest in transplant oncology. This is not only reflected by constant refinements to the criteria for LT in patients with HCC, but especially by efforts to expand indications to other primary and secondary liver malignancies. With new patient-centred oncological treatments on the rise and new technologies to expand the donor pool, the field has the chance to come full circle. In this review, we focus on the concept of transplant oncology, current indications, as well as technical and ethical aspects in the context of donor organs as precious resources.

Published in JHEP Reports

ISSN: 2589-5559 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://www.journals.elsevier.com/jhep-reports

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