Nature Communications (Mar 2017)

Circulating tumour DNA reflects treatment response and clonal evolution in chronic lymphocytic leukaemia

  • Paul Yeh,
  • Tane Hunter,
  • Devbarna Sinha,
  • Sarah Ftouni,
  • Elise Wallach,
  • Damian Jiang,
  • Yih-Chih Chan,
  • Stephen Q. Wong,
  • Maria Joao Silva,
  • Ravikiran Vedururu,
  • Kenneth Doig,
  • Enid Lam,
  • Gisela Mir Arnau,
  • Timothy Semple,
  • Meaghan Wall,
  • Andjelija Zivanovic,
  • Rishu Agarwal,
  • Pasquale Petrone,
  • Kate Jones,
  • David Westerman,
  • Piers Blombery,
  • John F. Seymour,
  • Anthony T. Papenfuss,
  • Mark A. Dawson,
  • Constantine S. Tam,
  • Sarah-Jane Dawson

DOI
https://doi.org/10.1038/ncomms14756
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 7

Abstract

Read online

Disease monitoring of chronic lymphocytic leukaemia (CLL) is a challenge. Here, the authors show that serial ctDNA analysis in 32 CLL patients allows monitoring of clonal dynamics over time, and identifies the emergence of genomic changes associated with Richter’s syndrome.