Visible-light promoted regioselective amination and alkylation of remote C(sp3)-H bonds

Quanping Guo; Qiang Peng; Hongli Chai; Yumei Huo; Shan Wang; Zhaoqing Xu

doi:10.1038/s41467-020-15167-2

Nature Communications (Mar 2020)

Visible-light promoted regioselective amination and alkylation of remote C(sp3)-H bonds

Quanping Guo,
Qiang Peng,
Hongli Chai,
Yumei Huo,
Shan Wang,
Zhaoqing Xu

Affiliations

Quanping Guo: Institute of Drug Design & Synthesis, Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Science, Lanzhou University
Qiang Peng: Institute of Drug Design & Synthesis, Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Science, Lanzhou University
Hongli Chai: Institute of Drug Design & Synthesis, Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Science, Lanzhou University
Yumei Huo: Institute of Drug Design & Synthesis, Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Science, Lanzhou University
Shan Wang: Institute of Drug Design & Synthesis, Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Science, Lanzhou University
Zhaoqing Xu: Institute of Drug Design & Synthesis, Institute of Pharmacology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Science, Lanzhou University

DOI: https://doi.org/10.1038/s41467-020-15167-2
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

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C-N bond forming is an established strategy to form amines, which are quintessential in chemical synthesis and in nature. Here, the authors report three classes of photoredox reactions, involving C(sp3)-N coupling between N-centered radicals and alkyl radicals and C(sp3)- C(sp3) coupling via C(sp3)-H alkylation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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