Relationship of Serum Pentraxin-3 with Peripheral Arterial Disease

Abstract

Aim: Atherosclerosis is a chronic inflammatory process associated with peripheral artery disease (PAD). The aim of this study was to investigate the role of pentraxin (PTX) as an inflammatory marker in the pathogenesis of PAD.Materials and Methods: This cross-sectional clinical study was performed at the tertiary university hospital emergency department and cardiovascular surgery departments in Turkey. The purpose was to determine the value of PTX3 in the diagnosis of PAD. This study was performed on 43 symptomatic patients aged >18 years and diagnosed with PAD.Results: Median PTX3 value was 1.027 (25–75th percentile: 0.395–2.902) in the control group and 0.585 (25–75th percentiles: 0.406–5.467) in the PAD group (p=0.913). A comparison of PTX3 with ankle brachial index (ABI) values revealed a weak and non-significant correlation (rho: 0.016, p=0.886). Analysis of PTX3 values with other parameters (age, systolic and diastolic blood pressure, heart rate, respiratory rate, temperature, and SpO2) revealed no significant correlation with any of the other parameters.Conclusion: Our findings indicate that PTX3 levels cannot be used as a marker in patients with the chronic process of PAD.

Keywords

• Atherosclerosis
• inflammation
• pentraxin-3
• peripheral arterial disease