Molecular & Cellular Oncology (Jan 2020)

RAS-driven oncogenesis is supported by downstream antioxidant programs

  • Jonathan K. M. Lim,
  • Gabriel Leprivier,
  • Poul H. Sorensen

DOI
https://doi.org/10.1080/23723556.2019.1654814
Journal volume & issue
Vol. 7, no. 1

Abstract

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In our recent study, we demonstrated that oncogenic RAS (rat sarcoma)-mediated transformation and tumorigenesis are supported by transcriptional induction of a crucial antioxidant component, SLC7A11 (solute carrier family 7 member 11), otherwise known as XCT, a gene encoding the cystine/glutamate transporter. Our data highlight that this promotes the biosynthesis of glutathione, in turn allowing RAS transformed cells to mitigate tumorigenesis-linked oxidative stress.