Examining the practical importance of nonstationary cardio-respiratory coupling detection in breathing training: a methodological appraisal

Abstract

This study investigates changes in cardiorespiratory coupling during clinic breathing training and its impact on autonomic nervous functioning compared with heart rate variability (HRV). A total of 39 subjects undergoing dynamic electrocardiogram-recorded breathing training were analyzed. Subjects were divided into early- and late-training periods, and further categorized based on changes in HRV indexes. Subtypes were identified using time-frequency cardiorespiratory coupling diagrams. Significant differences were observed in the high-frequency (HF) index between training stages in the subgroup with increasing HF-HRV (p = 0.0335). Both unimodal and bimodal subtypes showed significant high-frequency coupling (HFC) in the mid-training period compared with early and late stages (both p < 0.0001), suggesting improved parasympathetic cardiac regulation or reduced sympathetic control. This study highlights the potential of nonstationary cardiorespiratory coupling analysis alongside traditional HRV in evaluating the therapeutic effect of breathing training on autonomic nervous function. Cardiorespiratory coupling analysis could provide valuable adjunctive information to HRV measures for assessing the impact of breathing training.

Keywords

• Breathing training
• Heart rate variability
• Autonomic nervous system
• Cardiorespiratory coupling
• Nonstationary signals