Nature Communications (Sep 2017)

Oligodendroglial excitability mediated by glutamatergic inputs and Nav1.2 activation

  • Emmanuelle Berret,
  • Tara Barron,
  • Jie Xu,
  • Emily Debner,
  • Eun Jung Kim,
  • Jun Hee Kim

DOI
https://doi.org/10.1038/s41467-017-00688-0
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 15

Abstract

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Axon-glial communication is important for myelination. Here the authors show that during postnatal development in rats, a subpopulation of pre-myelinating oligodendrocytes in the auditory brainstem receive excitatory inputs and can generate Nav 1.2-driven action potentials, and that such process promotes myelination.