Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals

Thomas R. Gawriluk; Jennifer Simkin; Katherine L. Thompson; Shishir K. Biswas; Zak Clare-Salzler; John M. Kimani; Stephen G. Kiama; Jeramiah J. Smith; Vanessa O. Ezenwa; Ashley W. Seifert

doi:10.1038/ncomms11164

Nature Communications (Apr 2016)

Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals

Thomas R. Gawriluk,
Jennifer Simkin,
Katherine L. Thompson,
Shishir K. Biswas,
Zak Clare-Salzler,
John M. Kimani,
Stephen G. Kiama,
Jeramiah J. Smith,
Vanessa O. Ezenwa,
Ashley W. Seifert

Affiliations

Thomas R. Gawriluk: Department of Biology, University of Kentucky
Jennifer Simkin: Department of Biology, University of Kentucky
Katherine L. Thompson: Department of Statistics, University of Kentucky
Shishir K. Biswas: Department of Biology, University of Kentucky
Zak Clare-Salzler: Department of Biology, University of Kentucky
John M. Kimani: Department of Veterinary Anatomy and Physiology, University of Nairobi
Stephen G. Kiama: Department of Veterinary Anatomy and Physiology, University of Nairobi
Jeramiah J. Smith: Department of Biology, University of Kentucky
Vanessa O. Ezenwa: Odum School of Ecology, University of Georgia
Ashley W. Seifert: Department of Biology, University of Kentucky

DOI: https://doi.org/10.1038/ncomms11164
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 16

Abstract

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The extent to which mammals and other vertebrates share similar mechanisms of tissue regeneration is unclear. Here, the authors use an ear punch assay in spiny mice, which regenerate fully, to show blastema formation and mesenchymal cell proliferation as cell cycle regulators p21 and p27 remain cytoplasmic.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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