Nature Communications (Jan 2020)

Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform

  • Da Li,
  • Tiefeng Cao,
  • Xiaoli Sun,
  • Sungho Jin,
  • Di Xie,
  • Xinmei Huang,
  • Xiaoyong Yang,
  • Gordon G. Carmichael,
  • Hugh S. Taylor,
  • Sabrina Diano,
  • Yingqun Huang

DOI
https://doi.org/10.1038/s41467-019-14185-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 11

Abstract

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The HNF4α gene contains two promoters, which are thought to be active in the fetal and adult liver, the latter contributing to hepatic glucose production. Here the authors show that the fetal isoform of HNF4a is induced in mouse livers upon fasting and in type-2 diabetes in a manner regulated by TET3.