Nature Communications (Sep 2021)
Disrupting biological sensors of force promotes tissue regeneration in large organisms
- Kellen Chen,
- Sun Hyung Kwon,
- Dominic Henn,
- Britta A. Kuehlmann,
- Ruth Tevlin,
- Clark A. Bonham,
- Michelle Griffin,
- Artem A. Trotsyuk,
- Mimi R. Borrelli,
- Chikage Noishiki,
- Jagannath Padmanabhan,
- Janos A. Barrera,
- Zeshaan N. Maan,
- Teruyuki Dohi,
- Chyna J. Mays,
- Autumn H. Greco,
- Dharshan Sivaraj,
- John Q. Lin,
- Tobias Fehlmann,
- Alana M. Mermin-Bunnell,
- Smiti Mittal,
- Michael S. Hu,
- Alsu I. Zamaleeva,
- Andreas Keller,
- Jayakumar Rajadas,
- Michael T. Longaker,
- Michael Januszyk,
- Geoffrey C. Gurtner
Affiliations
- Kellen Chen
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Sun Hyung Kwon
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Dominic Henn
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Britta A. Kuehlmann
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Ruth Tevlin
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Clark A. Bonham
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Michelle Griffin
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Artem A. Trotsyuk
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Mimi R. Borrelli
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Chikage Noishiki
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Jagannath Padmanabhan
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Janos A. Barrera
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Zeshaan N. Maan
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Teruyuki Dohi
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Chyna J. Mays
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Autumn H. Greco
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Dharshan Sivaraj
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- John Q. Lin
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Tobias Fehlmann
- Clinical Bioinformatics, Saarland University
- Alana M. Mermin-Bunnell
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Smiti Mittal
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Michael S. Hu
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Alsu I. Zamaleeva
- Biomaterials and Advanced Drug Delivery Laboratory, Stanford University
- Andreas Keller
- Clinical Bioinformatics, Saarland University
- Jayakumar Rajadas
- Biomaterials and Advanced Drug Delivery Laboratory, Stanford University
- Michael T. Longaker
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Michael Januszyk
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- Geoffrey C. Gurtner
- Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-25410-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
Humans and other large mammals heal wounds by forming fibrotic scar tissue with diminished function. Here, the authors show that disrupting mechanotransduction through the focal adhesion kinase pathway in large animals accelerates healing, prevents fibrosis, and enhances skin regeneration.
