Journal of Family Medicine and Primary Care (Nov 2024)

The investigation of the relationship between vitamin D level and severity of diabetic ketoacidosis in new cases of type 1 diabetes in children referred to Hazrat-E- Ali-Asghar Hospital in 2021

  • Seyed Salaheddin Nabavi,
  • Fahimeh Soheilipour,
  • Motahare Aghajani Delavar,
  • Mahsa Javaherchian,
  • Pegah Karimian,
  • Shabahang Jafarnejad,
  • Hamidreza Khoshnezhad Ebrahimi,
  • Atoosa Mostafavi,
  • Seyedeh Mahsa Mahmoudinezhad Dezfouli,
  • Somayeh Esmaeilian,
  • Saeideh Iranmanesh

DOI
https://doi.org/10.4103/jfmpc.jfmpc_375_24
Journal volume & issue
Vol. 13, no. 11
pp. 4943 – 4948

Abstract

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Background and Purpose: According to the role of 25-hydroxyvitamin D (25OHD) in glucose homeostasis and immune modulation, vitamin D deficiency may be associated with type 1 diabetes and diabetic ketoacidosis (DKA). Therefore, this study was conducted with the aim of investigation of the relationship between the vitamin D level and severity of diabetic ketoacidosis in new cases of type 1 diabetes in children referred to Hazrat-E-Ali-Asghar Hospital in 2021. Methods: The present study is based on a cross-sectional study. The population studied in this research includes new cases of children with type 1 diabetes referred to Ali Asghar Children’s Hospital in Tehran in 2021. The data analysis was performed using SPSS version 23 software and a significance level of less than 0.05 was considered. Results: In total, 112 people were included in the study. The difference between the three groups of severity of ketoacidosis in blood pH and bicarbonate level was significant (P < 0.001). The comparison of serum vitamin D levels in different severity of ketoacidosis showed a significant difference between the three groups (P = 0.013), which seems to be caused by the significant difference between the severe and mild ketoacidosis groups. There was observed no significant difference between the gender subgroups and different serum vitamin D levels and also different severity of ketoacidosis (P = 0.801) and (P = 0.25). Conclusion: Based on the findings of our study, there is a significant relationship between vitamin D and the severity of diabetic ketoacidosis in children with type 2 diabetes. We suggest that routine evaluation of vitamin D levels in diabetic patients and prescribing vitamin D supplements to patients with vitamin D deficiency to prevent the risk of diabetic ketoacidosis.

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