A Simple, Rapid, and Cost-Effective PCR Procedure for Detection of <i>NUDT15</i> Gene Variants in Vietnamese Patients with Acute Lymphoblastic Leukemia

Abstract

Objective The NUDT15 variants impact thiopurine dose selection in acute lymphoblastic leukemia patients. The ability to rapidly detect variants is important in clinical practice. This study aims to develop a simple polymerase chain reaction (PCR) procedure for detecting NUDT15 variants in Vietnamese patients.

Keywords

• NUDT15
• tetra-primer ARMS PCR
• gene variant
• Vietnamese