Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics

Abstract

Abstract The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics.

Keywords

• Captopril montmorillonite
• Intercalation
• Intestine-specific controlled release
• Release kinetics