La2O3/Co3O4 nanocomposite modified screen printed electrode for voltammetric determination of sertraline

Abstract

La2O3/Co3O4 nanocomposite was synthesized and then used for the modification of screen-printed electrode (SPE) prior to the electrochemical determination of sertraline. A significant increment in peak current response was observed and peak potential also shifted towards less positive potentials showing the facilitated oxidation procedure at surface of modified SPE (La2O3/ /Co3O4/SPE). The quantitative determination of sertraline was carried out by using different pulse voltammetry and the anodic peak current was found to increase with increasing sertraline concentration in the linear range of 5.0400.0 μM with limit of detection as 1.0 μM. The prepared La2O3/Co3O4/SPE has been successfully used for detecting sertraline in sertraline tablet and urine samples with excellent recoveries.

Keywords

• sertraline
• electrochemical reaction
• differential pulse voltammetry