Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function

Yifei Miao; Nassim E. Ajami; Tse-Shun Huang; Feng-Mao Lin; Chih-Hong Lou; Yun-Ting Wang; Shuai Li; Jian Kang; Hannah Munkacsi; Mano R. Maurya; Shakti Gupta; Shu Chien; Shankar Subramaniam; Zhen Chen

doi:10.1038/s41467-017-02113-y

Nature Communications (Jan 2018)

Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function

Yifei Miao,
Nassim E. Ajami,
Tse-Shun Huang,
Feng-Mao Lin,
Chih-Hong Lou,
Yun-Ting Wang,
Shuai Li,
Jian Kang,
Hannah Munkacsi,
Mano R. Maurya,
Shakti Gupta,
Shu Chien,
Shankar Subramaniam,
Zhen Chen

Affiliations

Yifei Miao: Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope
Nassim E. Ajami: Bioinformatics and Systems Biology Graduate Program, University of California at San Diego
Tse-Shun Huang: Department of Bioengineering and Institute of Engineering in Medicine, University of California at San Diego
Feng-Mao Lin: Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope
Chih-Hong Lou: Genome Editing Core, Beckman Research Institute, City of Hope
Yun-Ting Wang: Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope
Shuai Li: Department of Medicine, University of California at San Diego
Jian Kang: Department of Medicine, University of California at San Diego
Hannah Munkacsi: Genome Editing Core, Beckman Research Institute, City of Hope
Mano R. Maurya: Department of Bioengineering and Institute of Engineering in Medicine, University of California at San Diego
Shakti Gupta: Department of Bioengineering and Institute of Engineering in Medicine, University of California at San Diego
Shu Chien: Department of Bioengineering and Institute of Engineering in Medicine, University of California at San Diego
Shankar Subramaniam: Department of Bioengineering and Institute of Engineering in Medicine, University of California at San Diego
Zhen Chen: Department of Diabetes Complications and Metabolism, Beckman Research Institute, City of Hope

DOI: https://doi.org/10.1038/s41467-017-02113-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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eNOS expression is dynamically regulated both transcriptionally and post-transcriptionally by various stimuli. Here the authors identify an enhancer-associated lncRNA (LEENE) that is co-regulated with, and enhances eNOS expression.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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