In vivo assessment of the anti-benign prostatic hyperplasia effect of hot ethanolic extract of flax seeds in male rats

Abstract

Background: The most widespread conditions that affected on primarily male population is Benign hyperplasia of the prostate BPH. Flax seeds has been reported to antiproliferation properties and exhibit antitumor. Aim: We assessed the impact of Flax seeds ethanolic excerpt on BPH within testosterone propionate induced model of rats. Methods: A pre-3-week daily injection of testosterone propionate (3 mg/kg BW) was used to induce BPH. Twenty male rats (200-240 gm) were randomly divided to 4 equal groups (n=5) negative Group under control was given PBS orally, corn oil S/C, BPH induced rats received 3mg/kg BW TP for 3 weeks, extract group received 50 mg/Kg extract twice daily for 2 weeks Finasteride group received standard drug 10 mg/Kg BW for 2 weeks. When the course of treatment is over, rats were sacrificed and the blood was collected and separated, the prostate of the rats were harvested for histological examination. Results: The results showed that flax seeds ethanolic extract could significantly (P [Open Vet J 2024; 14(8.000): 1928-1935]

Keywords

• finasteride
• flax seeds
• prostatic hyperplasia
• testosterone
• tissue morphology