Nature Communications (Jul 2019)
JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma
- Matthew Wong,
- Yuting Sun,
- Zhichao Xi,
- Giorgio Milazzo,
- Rebecca C. Poulos,
- Christoph Bartenhagen,
- Jessica L. Bell,
- Chelsea Mayoh,
- Nicholas Ho,
- Andrew E. Tee,
- Xiaoqiong Chen,
- Yang Li,
- Roberto Ciaccio,
- Pei Y. Liu,
- Chen C. Jiang,
- Qing Lan,
- Nisitha Jayatilleke,
- Belamy B. Cheung,
- Michelle Haber,
- Murray D. Norris,
- Xu D. Zhang,
- Glenn M. Marshall,
- Jenny Y. Wang,
- Stefan Hüttelmaier,
- Matthias Fischer,
- Jason W. H. Wong,
- Hongxi Xu,
- Giovanni Perini,
- Qihan Dong,
- Rani E. George,
- Tao Liu
Affiliations
- Matthew Wong
- Children’s Cancer Institute Australia
- Yuting Sun
- Children’s Cancer Institute Australia
- Zhichao Xi
- School of Pharmacy, Shanghai University of Traditional Chinese Medicine
- Giorgio Milazzo
- Department of Pharmacy and Biotechnology, University of Bologna
- Rebecca C. Poulos
- Prince of Wales Clinical School and Lowy Cancer Research Centre, UNSW Australia
- Christoph Bartenhagen
- Department of Experimental Pediatric Oncology, University Hospital, University of Cologne
- Jessica L. Bell
- Institute of Molecular Medicine, Martin Luther University
- Chelsea Mayoh
- Children’s Cancer Institute Australia
- Nicholas Ho
- Children’s Cancer Institute Australia
- Andrew E. Tee
- Children’s Cancer Institute Australia
- Xiaoqiong Chen
- School of Pharmacy, Shanghai University of Traditional Chinese Medicine
- Yang Li
- School of Pharmacy, Shanghai University of Traditional Chinese Medicine
- Roberto Ciaccio
- Department of Pharmacy and Biotechnology, University of Bologna
- Pei Y. Liu
- Children’s Cancer Institute Australia
- Chen C. Jiang
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- Qing Lan
- Department of Neurosurgery, the Second Affiliated Hospital of Soochow University
- Nisitha Jayatilleke
- Children’s Cancer Institute Australia
- Belamy B. Cheung
- Children’s Cancer Institute Australia
- Michelle Haber
- Children’s Cancer Institute Australia
- Murray D. Norris
- Children’s Cancer Institute Australia
- Xu D. Zhang
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- Glenn M. Marshall
- Children’s Cancer Institute Australia
- Jenny Y. Wang
- Children’s Cancer Institute Australia
- Stefan Hüttelmaier
- Institute of Molecular Medicine, Martin Luther University
- Matthias Fischer
- Department of Experimental Pediatric Oncology, University Hospital, University of Cologne
- Jason W. H. Wong
- Prince of Wales Clinical School and Lowy Cancer Research Centre, UNSW Australia
- Hongxi Xu
- School of Pharmacy, Shanghai University of Traditional Chinese Medicine
- Giovanni Perini
- Department of Pharmacy and Biotechnology, University of Bologna
- Qihan Dong
- Central Clinical School and Bosch Institute, The University of Sydney
- Rani E. George
- Department of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute and Boston Children’s Hospital
- Tao Liu
- Children’s Cancer Institute Australia
- DOI
- https://doi.org/10.1038/s41467-019-11132-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Although the gain in chromosome 17q21-ter is commonly associated with neuroblastoma, it is not clear which gene of this region mediates tumorigenesis. Here, the authors are showing that JMJD6, which locates in that region, is a neuroblastoma tumorigenic factor.
