Correlates of Healthy Aging in Geriatric HIV (CHANGE HIV)—CTN 314

Alice Zhabokritsky; Rosemarie Clarke; Ron Rosenes; Graham Smith; Mona Loutfy; Nisha Andany; Julian Falutz; Marina Klein; Marianne Harris; Silvia Guillemi; Darrell H. S. Tan; Gordon Arbess; Sharon Walmsley

doi:10.3390/v15020517

Viruses (Feb 2023)

Correlates of Healthy Aging in Geriatric HIV (CHANGE HIV)—CTN 314

Alice Zhabokritsky,
Rosemarie Clarke,
Ron Rosenes,
Graham Smith,
Mona Loutfy,
Nisha Andany,
Julian Falutz,
Marina Klein,
Marianne Harris,
Silvia Guillemi,
Darrell H. S. Tan,
Gordon Arbess,
Sharon Walmsley

Affiliations

Alice Zhabokritsky: Toronto General Research Institute, University Health Network, University of Toronto, Toronto, ON M5G 2M9, Canada
Rosemarie Clarke: Toronto General Research Institute, University Health Network, University of Toronto, Toronto, ON M5G 2M9, Canada
Ron Rosenes: Toronto General Research Institute, University Health Network, University of Toronto, Toronto, ON M5G 2M9, Canada
Graham Smith: Maple Leaf Medical Clinic, 14 College St, Toronto, ON M5G 1K2, Canada
Mona Loutfy: Women’s College Research Institute, Women’s College Hospital, Toronto, ON M5S 1B2, Canada
Nisha Andany: Sunnybrook Health Science Centre, University of Toronto, Toronto, ON M4N 3M5, Canada
Julian Falutz: Chronic Viral Illness Service, McGill University Health Centre, Montreal, QC H4A3J1, Canada
Marina Klein: Infectious Diseases and Immunity in Global Health Program, Research Institute of McGill University Health Centre, Montreal, QC H4A 3J1, Canada
Marianne Harris: BC Centre for Excellence in HIV/AIDS, University of British Columbia, 608-1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
Silvia Guillemi: Department of Family Medicine, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
Darrell H. S. Tan: St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada
Gordon Arbess: St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1W8, Canada
Sharon Walmsley: Toronto General Research Institute, University Health Network, University of Toronto, Toronto, ON M5G 2M9, Canada

DOI: https://doi.org/10.3390/v15020517
Journal volume & issue: Vol. 15, no. 2
p. 517

Abstract

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The Correlates of Healthy Aging in Geriatric HIV (CHANGE HIV) study, CTN 314, is the first Canadian cohort of people living with HIV aged 65 years and older. The cohort was established with the purpose of characterizing the multidimensional health status of this population and identifying factors influencing healthy aging. The study builds on the World Health Organization (WHO) Aging and Health conceptual framework, generating a comprehensive profile of health domains (physical, social, mental health, cognitive function, and quality of life), health determinants (biologic, personal, and environmental), and HIV-specific factors that may interact with and influence health in people aging with HIV. The data for the first 353 participants are presented, focusing on sociodemographic factors, comorbidities, coinfections, frailty, cognitive function, loneliness, and resilience using a sex/gender stratified analysis. The cohort thus far is 91% men and the median age is 70 years (range from 65 to 85). Several vulnerabilities were observed, including a high prevalence of comorbidities and frailty. Women especially faced financial insecurity and precarious social structures; a large proportion live alone and only 6% are married or in steady relationships. Identifying strategies to address these vulnerabilities will empower people aging with HIV to optimize their health, quality of life, and independence.

Published in Viruses

ISSN: 1999-4915 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/viruses

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