Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes

Dmitrii A. Aksenov; Nikolai A. Arutiunov; Vladimir V. Maliuga; Alexander V. Aksenov; Michael Rubin

doi:10.3762/bjoc.16.239

Beilstein Journal of Organic Chemistry (Nov 2020)

Synthesis of imidazo[1,5-a]pyridines via cyclocondensation of 2-(aminomethyl)pyridines with electrophilically activated nitroalkanes

Dmitrii A. Aksenov,
Nikolai A. Arutiunov,
Vladimir V. Maliuga,
Alexander V. Aksenov,
Michael Rubin

Affiliations

Dmitrii A. Aksenov: Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, Russian Federation
Nikolai A. Arutiunov: Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, Russian Federation
Vladimir V. Maliuga: Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, Russian Federation
Alexander V. Aksenov: Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, Russian Federation
Michael Rubin: Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, Russian Federation

DOI: https://doi.org/10.3762/bjoc.16.239
Journal volume & issue: Vol. 16, no. 1
pp. 2903 – 2910

Abstract

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Imidazo[1,5-a]pyridines were efficiently prepared via the cyclization of 2-picolylamines with nitroalkanes electrophilically activated in the presence of phosphorous acid in polyphosphoric acid (PPA) medium.

Published in Beilstein Journal of Organic Chemistry

ISSN: 1860-5397 (Online)
Publisher: Beilstein-Institut
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.beilstein-journals.org/bjoc

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