Vaccines (Aug 2022)

Evaluation of the Anti-Spike (RDB) IgG Titer among Workers Employed at the University of Pisa Vaccinated with Different Types of SARS-CoV-2 Vaccines

  • Rudy Foddis,
  • Riccardo Marino,
  • Roberto Silvestri,
  • Poupak Fallahi,
  • Salvio Perretta,
  • Christian Garaffa,
  • Riccardo Morganti,
  • Martina Corsi,
  • Jonathan Mennucci,
  • Francesco Porciatti,
  • Gianluca Nerli,
  • Rodolfo Buselli,
  • Antonello Veltri,
  • Fabrizio Caldi,
  • Giovanni Guglielmi,
  • Grazia Luchini,
  • Silvia Briani,
  • Donatella Talini,
  • Francesco Cipriani

DOI
https://doi.org/10.3390/vaccines10081244
Journal volume & issue
Vol. 10, no. 8
p. 1244

Abstract

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With the development of SARS-CoV-2 vaccines, many authors started evaluating the immunization efficacy of the available vaccines mainly through sero-positivity tests or by a quantitative assessment of the IgG against the spike protein of SARS-CoV-2 virus in vaccinated subjects. In this work, we compared the titers resulting from vaccination and tried to understand the potential factors affecting the immune response to the available SARS-CoV-2 vaccines. This study was conducted on 670 volunteers employed at the University of Pisa and undergoing a health surveillance program at the University Hospital of Pisa. For each participant, 10 mL of blood, information about contacts with confirmed cases of COVID-19, age, sex, SARS-CoV-2 vaccination status, previous SARS-CoV-2 infection and symptoms, type of vaccine and the date of administration were collected. In the multivariate analysis, the type of vaccine, the presence of symptoms in SARS-CoV-2 positive individuals, and the distance from the second dose significantly affected the antibody titer; the combined vaccination resulted in a faster decay over time compared with the other types of vaccination. No significant differences were observed between Spikevax and Comirnaty (p > 0.05), while the antibody levels remain more stable in subjects undergoing Vaxzevria vaccination (p < 0.01) compared with mRNA-based ones.

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