Nature Communications (Sep 2019)

MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription–replication conflicts

  • Emily Yun-Chia Chang,
  • Shuhe Tsai,
  • Maria J. Aristizabal,
  • James P. Wells,
  • Yan Coulombe,
  • Franciele F. Busatto,
  • Yujia A. Chan,
  • Arun Kumar,
  • Yi Dan Zhu,
  • Alan Ying-Hsu Wang,
  • Louis-Alexandre Fournier,
  • Philip Hieter,
  • Michael S. Kobor,
  • Jean-Yves Masson,
  • Peter C. Stirling

DOI
https://doi.org/10.1038/s41467-019-12271-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 15

Abstract

Read online

Accumulations of R-loops can lead to genome instability. Here the authors reveal a role for the MRN complex in suppressing R-loops and associated DNA damage at transcription–replication conflicts.