Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

Jian Jing Siew; Hui-Mei Chen; Huan-Yuan Chen; Hung-Lin Chen; Chiung-Mei Chen; Bing-Wen Soong; Yih-Ru Wu; Ching-Pang Chang; Yi-Chen Chan; Chun-Hung Lin; Fu-Tong Liu; Yijuang Chern

doi:10.1038/s41467-019-11441-0

Nature Communications (Aug 2019)

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington’s disease

Jian Jing Siew,
Hui-Mei Chen,
Huan-Yuan Chen,
Hung-Lin Chen,
Chiung-Mei Chen,
Bing-Wen Soong,
Yih-Ru Wu,
Ching-Pang Chang,
Yi-Chen Chan,
Chun-Hung Lin,
Fu-Tong Liu,
Yijuang Chern

Affiliations

Jian Jing Siew: Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica
Hui-Mei Chen: Institute of Biomedical Sciences, Academia Sinica
Huan-Yuan Chen: Institute of Biomedical Sciences, Academia Sinica
Hung-Lin Chen: Institute of Biomedical Sciences, Academia Sinica
Chiung-Mei Chen: Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and College of Medicine, Chang-Gung University
Bing-Wen Soong: Department of Neurology, Shuang Ho Hospital, and Taipei Neuroscience Institute, Taipei Medical University
Yih-Ru Wu: Department of Neurology, Chang Gung Memorial Hospital, Linkou Medical Center and College of Medicine, Chang-Gung University
Ching-Pang Chang: Institute of Biomedical Sciences, Academia Sinica
Yi-Chen Chan: Institute of Biological Chemistry, Academia Sinica
Chun-Hung Lin: Institute of Biological Chemistry, Academia Sinica
Fu-Tong Liu: Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica
Yijuang Chern: Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica

DOI: https://doi.org/10.1038/s41467-019-11441-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 18

Abstract

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The authors show that Galectin-3 is up–regulated in brain tissues from patients and a mouse model of Huntington’s disease (HD) and correlates with disease severity. Galectin-3 accumulates at damaged lysosomes in HD microglia, prevents the clearance of damaged lysosomes, and promotes inflammation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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