Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect

Kengo Abe; Akihiro Yamashita; Miho Morioka; Nanao Horike; Yoshiaki Takei; Saeko Koyamatsu; Keisuke Okita; Shuichi Matsuda; Noriyuki Tsumaki

doi:10.1038/s41467-023-36408-0

Nature Communications (Feb 2023)

Engraftment of allogeneic iPS cell-derived cartilage organoid in a primate model of articular cartilage defect

Kengo Abe,
Akihiro Yamashita,
Miho Morioka,
Nanao Horike,
Yoshiaki Takei,
Saeko Koyamatsu,
Keisuke Okita,
Shuichi Matsuda,
Noriyuki Tsumaki

Affiliations

Kengo Abe: Department of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka University
Akihiro Yamashita: Department of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka University
Miho Morioka: Department of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka University
Nanao Horike: Department of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka University
Yoshiaki Takei: Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University
Saeko Koyamatsu: Department of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka University
Keisuke Okita: Department of Life Science Frontiers, Center for iPS Cell Research and Application, Kyoto University
Shuichi Matsuda: Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University
Noriyuki Tsumaki: Department of Tissue Biochemistry, Graduate School of Medicine and Frontier Biosciences, Osaka University

DOI: https://doi.org/10.1038/s41467-023-36408-0
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 16

Abstract

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Allogeneic iPSC-derived cartilage organoids survive and integrate with surrounding native cartilage without immune reactions in a primate model of chondral defects in the knee joints, being remodeled and functioning as articular cartilage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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