Nature Communications (Sep 2021)
Multi-level inhibition of coronavirus replication by chemical ER stress
- Mohammed Samer Shaban,
- Christin Müller,
- Christin Mayr-Buro,
- Hendrik Weiser,
- Johanna Meier-Soelch,
- Benadict Vincent Albert,
- Axel Weber,
- Uwe Linne,
- Torsten Hain,
- Ilya Babayev,
- Nadja Karl,
- Nina Hofmann,
- Stephan Becker,
- Susanne Herold,
- M. Lienhard Schmitz,
- John Ziebuhr,
- Michael Kracht
Affiliations
- Mohammed Samer Shaban
- Rudolf Buchheim Institute of Pharmacology, Justus Liebig University
- Christin Müller
- Institute of Medical Virology, Justus Liebig University
- Christin Mayr-Buro
- Rudolf Buchheim Institute of Pharmacology, Justus Liebig University
- Hendrik Weiser
- Rudolf Buchheim Institute of Pharmacology, Justus Liebig University
- Johanna Meier-Soelch
- Rudolf Buchheim Institute of Pharmacology, Justus Liebig University
- Benadict Vincent Albert
- Rudolf Buchheim Institute of Pharmacology, Justus Liebig University
- Axel Weber
- Rudolf Buchheim Institute of Pharmacology, Justus Liebig University
- Uwe Linne
- Mass spectrometry facility of the Department of Chemistry, Philipps University
- Torsten Hain
- Institute of Medical Microbiology, Justus Liebig University
- Ilya Babayev
- Rudolf Buchheim Institute of Pharmacology, Justus Liebig University
- Nadja Karl
- Institute of Medical Virology, Justus Liebig University
- Nina Hofmann
- Bioinformatics and Systems Biology, Justus Liebig University
- Stephan Becker
- Institute of Virology, Philipps University
- Susanne Herold
- Department of Internal Medicine II for Pulmonary and Critical Care Medicine and Infectious Diseases, Justus Liebig University, and Institute for Lung Health (ILH)
- M. Lienhard Schmitz
- German Center for Lung Research (DZL) and Universities of Giessen and Marburg Lung Center (UGMLC)
- John Ziebuhr
- Institute of Medical Virology, Justus Liebig University
- Michael Kracht
- Rudolf Buchheim Institute of Pharmacology, Justus Liebig University
- DOI
- https://doi.org/10.1038/s41467-021-25551-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 20
Abstract
Here, Shaban et al. show that coronaviruses modulate ER stress and the unfolded protein response. The ER stress inducer thapsigargin exerts potent antiviral effects, partially reverses the virus-induced translational shut-down, reprograms the host proteome and suppresses autophagic flux, thereby inhibiting coronavirus replication at multiple levels.
