Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin

Abstract

The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment.

Keywords

• total synthesis
• stereochemical determination/revision
• carmabin A
• dragomabin