Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials

Oliver Birkholz; Jonathan R. Burns; Christian P. Richter; Olympia E. Psathaki; Stefan Howorka; Jacob Piehler

doi:10.1038/s41467-018-02905-w

Nature Communications (Apr 2018)

Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials

Oliver Birkholz,
Jonathan R. Burns,
Christian P. Richter,
Olympia E. Psathaki,
Stefan Howorka,
Jacob Piehler

Affiliations

Oliver Birkholz: Department of Biology and Center for Cellular Nanoanalytics (CellNanOs), University of Osnabrück
Jonathan R. Burns: Department of Chemistry, Institute of Structural and Molecular Biology, University College London
Christian P. Richter: Department of Biology and Center for Cellular Nanoanalytics (CellNanOs), University of Osnabrück
Olympia E. Psathaki: Department of Biology and Center for Cellular Nanoanalytics (CellNanOs), University of Osnabrück
Stefan Howorka: Department of Chemistry, Institute of Structural and Molecular Biology, University College London
Jacob Piehler: Department of Biology and Center for Cellular Nanoanalytics (CellNanOs), University of Osnabrück

DOI: https://doi.org/10.1038/s41467-018-02905-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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DNA nanopores can span lipid bilayers but how they interact with lipids is not known. Here the authors establish at single-molecule level the insertion mechanism and show that DNA nanopores can locally cluster and remodel membranes, and stabilize autonomously formed lipid nanotubes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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