Nature Communications (Feb 2020)
Mutations in the HPV16 genome induced by APOBEC3 are associated with viral clearance
- Bin Zhu,
- Yanzi Xiao,
- Meredith Yeager,
- Gary Clifford,
- Nicolas Wentzensen,
- Michael Cullen,
- Joseph F. Boland,
- Sara Bass,
- Mia K. Steinberg,
- Tina Raine-Bennett,
- DongHyuk Lee,
- Robert D. Burk,
- Maisa Pinheiro,
- Lei Song,
- Michael Dean,
- Chase W. Nelson,
- Laurie Burdett,
- Kai Yu,
- David Roberson,
- Thomas Lorey,
- Silvia Franceschi,
- Philip E. Castle,
- Joan Walker,
- Rosemary Zuna,
- Mark Schiffman,
- Lisa Mirabello
Affiliations
- Bin Zhu
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Yanzi Xiao
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Meredith Yeager
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Gary Clifford
- Infections and Cancer Epidemiology Group, International Agency for Research on Cancer
- Nicolas Wentzensen
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Michael Cullen
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Joseph F. Boland
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Sara Bass
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Mia K. Steinberg
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Tina Raine-Bennett
- Women’s Health Research Institute, Division of Research, Kaiser Permanente Northern California
- DongHyuk Lee
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Robert D. Burk
- Departments of Pediatrics, Microbiology and Immunology, and Obstetrics & Gynecology and Women’s Health, Albert Einstein College of Medicine
- Maisa Pinheiro
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Lei Song
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Michael Dean
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Chase W. Nelson
- Sackler Institute for Comparative Genomics, American Museum of Natural History
- Laurie Burdett
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Kai Yu
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- David Roberson
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Thomas Lorey
- Regional Laboratory, Kaiser Permanente Northern California
- Silvia Franceschi
- CRO Aviano National Cancer Institute IRCCS
- Philip E. Castle
- Department of Epidemiology and Population Health, Albert Einstein College of Medicine
- Joan Walker
- University of Oklahoma Health Sciences Center
- Rosemary Zuna
- University of Oklahoma Health Sciences Center
- Mark Schiffman
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Lisa Mirabello
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-020-14730-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
The APOBEC mutational signature is prevalent in different tumour types. Here, using HPV16- positive cervical samples, the authors show that the signature is more prevalent in the viral genome of benign or clearing HPV16 infections compared to the viral genomes of the more advanced precancerous lesions or cervical cancer.
