Interplay of protein corona and immune cells controls blood residency of liposomes

Francesca Giulimondi; Luca Digiacomo; Daniela Pozzi; Sara Palchetti; Elisabetta Vulpis; Anna Laura Capriotti; Riccardo Zenezini Chiozzi; Aldo Laganà; Heinz Amenitsch; Laura Masuelli; Giovanna Peruzzi; Morteza Mahmoudi; Isabella Screpanti; Alessandra Zingoni; Giulio Caracciolo

doi:10.1038/s41467-019-11642-7

Nature Communications (Aug 2019)

Interplay of protein corona and immune cells controls blood residency of liposomes

Francesca Giulimondi,
Luca Digiacomo,
Daniela Pozzi,
Sara Palchetti,
Elisabetta Vulpis,
Anna Laura Capriotti,
Riccardo Zenezini Chiozzi,
Aldo Laganà,
Heinz Amenitsch,
Laura Masuelli,
Giovanna Peruzzi,
Morteza Mahmoudi,
Isabella Screpanti,
Alessandra Zingoni,
Giulio Caracciolo

Affiliations

Francesca Giulimondi: Department of Molecular Medicine, Sapienza University of Rome
Luca Digiacomo: Department of Molecular Medicine, Sapienza University of Rome
Daniela Pozzi: Department of Molecular Medicine, Sapienza University of Rome
Sara Palchetti: Department of Molecular Medicine, Sapienza University of Rome
Elisabetta Vulpis: Department of Molecular Medicine, Sapienza University of Rome
Anna Laura Capriotti: Department of Chemistry, Sapienza University of Rome
Riccardo Zenezini Chiozzi: Department of Chemistry, Sapienza University of Rome
Aldo Laganà: Department of Chemistry, Sapienza University of Rome
Heinz Amenitsch: Institute of inorganic Chemistry, Graz University of Technology
Laura Masuelli: Department of Experimental Medicine, Sapienza University of Rome
Giovanna Peruzzi: Istituto Italiano di Tecnologia, Center for Life Nano Science@Sapienza
Morteza Mahmoudi: Precision Health Program, Michigan State University
Isabella Screpanti: Department of Molecular Medicine, Sapienza University of Rome
Alessandra Zingoni: Department of Molecular Medicine, Sapienza University of Rome
Giulio Caracciolo: Department of Molecular Medicine, Sapienza University of Rome

DOI: https://doi.org/10.1038/s41467-019-11642-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Protein corona formation is known to have significant effects upon nanomaterials application. Here, the authors investigate the creation of a protein coating on liposomes with the aim of improving liposome circulation time by avoiding leukocyte capture and demonstrated application in vitro and ex vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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