A Novel Fluorescent Probe for Hydrogen Peroxide and Its Application in Bio-Imaging

Yingying Zuo; Yang Jiao; Chunming Ma; Chunying Duan

doi:10.3390/molecules26113352

Molecules (Jun 2021)

A Novel Fluorescent Probe for Hydrogen Peroxide and Its Application in Bio-Imaging

Yingying Zuo,
Yang Jiao,
Chunming Ma,
Chunying Duan

Affiliations

Yingying Zuo: State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
Yang Jiao: State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
Chunming Ma: State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
Chunying Duan: State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China

DOI: https://doi.org/10.3390/molecules26113352
Journal volume & issue: Vol. 26, no. 11
p. 3352

Abstract

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Hydrogen peroxide (H2O2) plays an important role in the human body and monitoring its level is meaningful due to the relationship between its level and diseases. A fluorescent sensor (CMB) based on coumarin was designed and its ability for detecting hydrogen peroxide by fluorescence signals was also studied. The CMB showed an approximate 25-fold fluorescence enhancement after adding H2O2 due to the interaction between the CMB and H2O2 and had the potential for detecting physiological H2O2. It also showed good biocompatibility and permeability, allowing it to penetrate cell membranes and zebrafish tissues, thus it can perform fluorescence imaging of H2O2 in living cells and zebrafish. This probe is a promising tool for monitoring the level of H2O2 in related physiological and pathological research.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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