Кардиоваскулярная терапия и профилактика (Feb 2017)

CLINICAL VALUE OF THE PARAMETERS OF LOCAL AND REGIONAL VASCULAR RIGIDITY, WAYS FOR PHARMACOLOGICAL CORRECTION

  • V. E. Oleynikov,
  • I. Ya. Moiseeva,
  • E. A. Melnikova,
  • Yu. A. Tomashevskaya,
  • I. V. Avdeeva

DOI
https://doi.org/10.15829/1728-8800-2017-1-22-26
Journal volume & issue
Vol. 16, no. 1
pp. 22 – 26

Abstract

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Aim. To study the influence of age on the parameters of local vascular rigidity in healthy persons, and to assess correlations of carotid arteries rigidity in coronary heart disease (CHD) patients with arterial hypertension (AH) of 1-2 grades with assessment of vasoprotective effect of a sartan — antagonist of angiotensin II receptors (AAR).Material and methods. With an aim to study age and cardiovascular pathology influence on the parameters of local rigidity, 44 healthy persons included and 20 patients with AH of 1-2 grades comorbid with proven CHD. Local carotid stiffness was assessed by ultrasound examination of carotid arteries, My Lab 90 device with the technology of radiofrequency analysis of vessel wall condition — echo tracking. Also, the influence was analyzed, of 24-week therapy by one of sartans on structural and functional characteristics of carotid arteries.Results. Comparison of the results of local stiffness in healthy group showed the local pulse wave velocity (PWV) in the range from 5,9±0,7 m/s in those 30-39 year old to 6,6±1,1 m/s in normotonics >50 y.o., there were significant differences in those >50 y.o. comparing with participants <40 y.o. Analogical changes were shown for the stiffness index β. Together with normalized office blood pressure (BP), AAR treatment was followed by a decrease of local pressure in carotid arteries, and decrease of carotid PWV from 9,9 (9,1; 11,5) m/s to 8,3 (6,6; 8,6) m/s with regression by 17% (p<0,05). Positive influence of AAR on structural and functional properties of carotid arteries confirms the significant growth of the coefficient by 3,3% (p<0,05), and decrease of stiffness indexes α & β by 19,4% (р<0,05) and 19,9% (p<0,01), respectively.Conclusion. Parameters of local stiffness significantly correlated with anthropometric parameters, duration of AH, systolic and diastolic BP in patients with cardiovascular comorbidity. Therapy with sartan followed by not only normalization of BP, but improved the parameters of local arterial rigidity.

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