Nature Communications (Sep 2020)
The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution
- Alexej Ballhausen,
- Moritz Jakob Przybilla,
- Michael Jendrusch,
- Saskia Haupt,
- Elisabeth Pfaffendorf,
- Florian Seidler,
- Johannes Witt,
- Alejandro Hernandez Sanchez,
- Katharina Urban,
- Markus Draxlbauer,
- Sonja Krausert,
- Aysel Ahadova,
- Martin Simon Kalteis,
- Pauline L. Pfuderer,
- Daniel Heid,
- Damian Stichel,
- Johannes Gebert,
- Maria Bonsack,
- Sarah Schott,
- Hendrik Bläker,
- Toni Seppälä,
- Jukka-Pekka Mecklin,
- Sanne Ten Broeke,
- Maartje Nielsen,
- Vincent Heuveline,
- Julia Krzykalla,
- Axel Benner,
- Angelika Beate Riemer,
- Magnus von Knebel Doeberitz,
- Matthias Kloor
Affiliations
- Alexej Ballhausen
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Moritz Jakob Przybilla
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Michael Jendrusch
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Saskia Haupt
- Engineering Mathematics and Computing Lab (EMCL), Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University
- Elisabeth Pfaffendorf
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Florian Seidler
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Johannes Witt
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Alejandro Hernandez Sanchez
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Katharina Urban
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Markus Draxlbauer
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Sonja Krausert
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Aysel Ahadova
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Martin Simon Kalteis
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Pauline L. Pfuderer
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Daniel Heid
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Damian Stichel
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Johannes Gebert
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Maria Bonsack
- Immunotherapy and Immunoprevention, German Cancer Research Center (DKFZ)
- Sarah Schott
- Department of Obstetrics and Gynecology, University Hospital Heidelberg
- Hendrik Bläker
- Institute of Pathology, University Hospital Leipzig
- Toni Seppälä
- Department of Gastrointestinal Surgery, Helsinki University Hospital and University of Helsinki
- Jukka-Pekka Mecklin
- Department of Education and Research, Central Finland Central Hospital
- Sanne Ten Broeke
- Department of Clinical Genetics, Leiden University Medical Center
- Maartje Nielsen
- Department of Clinical Genetics, Leiden University Medical Center
- Vincent Heuveline
- Engineering Mathematics and Computing Lab (EMCL), Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University
- Julia Krzykalla
- Division of Biostatistics, German Cancer Research Center (DKFZ)
- Axel Benner
- Division of Biostatistics, German Cancer Research Center (DKFZ)
- Angelika Beate Riemer
- Immunotherapy and Immunoprevention, German Cancer Research Center (DKFZ)
- Magnus von Knebel Doeberitz
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- Matthias Kloor
- Department of Applied Tumor Biology, Institute of Pathology, University of Heidelberg
- DOI
- https://doi.org/10.1038/s41467-020-18514-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
DNA mismatch repair (MMR)-deficient cancers with microsatellite-instability are characterized by a high load of frameshift mutation-derived neoantigens. Here, by mapping the frameshift mutation landscape and predicting the immunogenicity of the resulting peptides, the authors show evidence of immunoediting in MMR-deficient colorectal and endometrial cancers.
