Frontiers in Allergy (May 2024)
Pre-asthma: a useful concept? A EUFOREA paper. Part 2—late onset eosinophilic asthma
- G. K. Scadding,
- G. K. Scadding,
- C. Gray,
- C. Gray,
- D. M. Conti,
- D. M. Conti,
- M. McDonald,
- V. Backer,
- G. Scadding,
- M. Bernal-Sprekelsen,
- M. Bernal-Sprekelsen,
- E. De Corso,
- Z. Diamant,
- Z. Diamant,
- Z. Diamant,
- Z. Diamant,
- C. Hopkins,
- M. Jesenak,
- M. Jesenak,
- M. Jesenak,
- P. Johansen,
- P. Johansen,
- J. Kappen,
- J. Mullol,
- D. Price,
- D. Price,
- S. Quirce,
- S. Reitsma,
- S. Toppila-Salmi,
- S. Toppila-Salmi,
- B. Senior,
- J. P. Thyssen,
- U. Wahn,
- P. W. Hellings,
- P. W. Hellings,
- P. W. Hellings
Affiliations
- G. K. Scadding
- Department of Allergy & Rhinology, Royal National ENT Hospital, London, United Kingdom
- G. K. Scadding
- Division of Immunity and Infection, University College, London, United Kingdom
- C. Gray
- Paediatric Allergist, Red Cross Children's Hospital and University of Cape Town, Cape Town, South Africa
- C. Gray
- Kidsallergy Centre, Cape Town, South Africa
- D. M. Conti
- The European Forum for Research and Education in Allergy and Airway Diseases Scientific Expert Team Members, Brussels, Belgium
- D. M. Conti
- Escuela de Doctorado UAM, Centro de Estudios de Posgrado, Universidad Autónoma de Madrid, Calle Francisco Tomás y Valiente, no 2, Ciudad Universitaria de Cantoblanco, Madrid, Spain
- M. McDonald
- The Allergy Clinic, Blairgowrie, Randburg, South Africa
- V. Backer
- Department of Otorhinolaryngology, Head & Neck Surgery, and Audiology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark
- G. Scadding
- Allergy, Royal Brompton Hospital, London, United Kingdom
- M. Bernal-Sprekelsen
- 0Otolaryngology-Department, Clinic Barcelona, Barcelona, Spain
- M. Bernal-Sprekelsen
- 1Otolaryngology-Department, University of Barcelona, Barcelona, Spain
- E. De Corso
- 2Otolaryngology Head and Neck Surgery, A. Gemelli University Hospital Foundation IRCCS, Rome, Italy
- Z. Diamant
- 3Department of Respiratory Medicine & Allergology, Institute for Clinical Science, Skane University Hospital, Lund University, Lund, Sweden
- Z. Diamant
- 4Department of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic
- Z. Diamant
- 5Department Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
- Z. Diamant
- 6Department of Microbiology Immunology & Transplantation, KU Leuven, Catholic University of Leuven, Leuven, Belgium
- C. Hopkins
- 7Department of Rhinology and Skull Base Surgery, Guy’s and St Thomas’ Hospital NHS Foundation Trust, London, United Kingdom
- M. Jesenak
- 8Department of Clinical Immunology and Allergology, University Teaching Hospital in Martin, Martin, Slovak Republic
- M. Jesenak
- 9Department of Paediatrics, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Teaching Hospital in Martin, Martin, Slovak Republic
- M. Jesenak
- 0Department of Pulmonology and Phthisiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Teaching Hospital in Martin, Martin, Slovak Republic
- P. Johansen
- 1Department of Dermatology, University of Zurich, Zurich, Switzerland
- P. Johansen
- 2Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
- J. Kappen
- 3Department of Pulmonology, STZ Centre of Excellence for Asthma, COPD and Respiratory Allergy, Franciscus Gasthuis & Vlietland, Rotterdam, Netherlands
- J. Mullol
- 4Rhinology Unit and Smell Clinic, ENT Department, Hospital Clínic, FRCB-IDIBAPS, Universitat de Barcelona, CIBERES, Barcelona, Spain
- D. Price
- 5Observational and Pragmatic Research Institute, Singapore, Singapore
- D. Price
- 6Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
- S. Quirce
- 7Department of Allergy, La Paz University Hospital, IdiPAZ, Madrid, Spain
- S. Reitsma
- 8Department of Otorhinolarynogology and Head/Neck Surgery, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, Netherlands
- S. Toppila-Salmi
- 9Department of Otorhinolaryngology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
- S. Toppila-Salmi
- 0Department of Allergy, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
- B. Senior
- 1Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
- J. P. Thyssen
- 2Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
- U. Wahn
- 3Department for Pediatric Pneumology and Immunology, Charite University Medicine, Berlin, Germany
- P. W. Hellings
- 4Department of Otorhinolaryngology-Head and Neck Surgery, University Hospitals, Leuven, Belgium
- P. W. Hellings
- 5Laboratory of Allergy and Clinical Immunology, University Hospitals Leuven, Leuven, Belgium
- P. W. Hellings
- 6Upper Airways Research Laboratory, Department of Head and Skin, Ghent University, Ghent, Belgium
- DOI
- https://doi.org/10.3389/falgy.2024.1404735
- Journal volume & issue
-
Vol. 5
Abstract
The concept of pre-diabetes has led to provision of measures to reduce disease progression through identification of subjects at risk of diabetes. We previously considered the idea of pre-asthma in relation to allergic asthma and considered that, in addition to the need to improve population health via multiple measures, including reduction of exposure to allergens and pollutants and avoidance of obesity, there are several possible specific means to reduce asthma development in those most at risk (pre- asthma). The most obvious is allergen immunotherapy (AIT), which when given for allergic rhinitis (AR) has reasonable evidence to support asthma prevention in children (2) but also needs further study as primary prevention. In this second paper we explore the possibilities for similar actions in late onset eosinophilic asthma.
Keywords
- late onset asthma
- non-allergic rhinitis
- chronic rhinosinusitis with nasal polyps
- eosinophils
- mast cells
- virulence genes