Nature Communications (Jun 2016)
Tumour-initiating cell-specific miR-1246 and miR-1290 expression converge to promote non-small cell lung cancer progression
- Wen Cai Zhang,
- Tan Min Chin,
- Henry Yang,
- Min En Nga,
- Declan Patrick Lunny,
- Edwin Kok Hao Lim,
- Li Li Sun,
- Yin Huei Pang,
- Yi Ning Leow,
- Shanneen Rossellini Y Malusay,
- Priscilla Xin Hui Lim,
- Jeravan Zili Lee,
- Benedict Jian Wei Tan,
- Ng Shyh-Chang,
- Elaine Hsuen Lim,
- Wan Teck Lim,
- Daniel Shao Weng Tan,
- Eng Huat Tan,
- Bee Choo Tai,
- Ross Andrew Soo,
- Wai Leong Tam,
- Bing Lim
Affiliations
- Wen Cai Zhang
- Genome Institute of Singapore
- Tan Min Chin
- Cancer Science Institute of Singapore, National University of Singapore
- Henry Yang
- Cancer Science Institute of Singapore, National University of Singapore
- Min En Nga
- Department of Pathology, National University Hospital
- Declan Patrick Lunny
- Institute of Medical Biology
- Edwin Kok Hao Lim
- Genome Institute of Singapore
- Li Li Sun
- Genome Institute of Singapore
- Yin Huei Pang
- Department of Pathology, National University Hospital
- Yi Ning Leow
- Genome Institute of Singapore
- Shanneen Rossellini Y Malusay
- Genome Institute of Singapore
- Priscilla Xin Hui Lim
- Genome Institute of Singapore
- Jeravan Zili Lee
- Genome Institute of Singapore
- Benedict Jian Wei Tan
- Genome Institute of Singapore
- Ng Shyh-Chang
- Genome Institute of Singapore
- Elaine Hsuen Lim
- Department of Respiratory Medicine, Tan Tock Seng Hospital
- Wan Teck Lim
- Department of Medical Oncology, National Cancer Centre Singapore
- Daniel Shao Weng Tan
- Genome Institute of Singapore
- Eng Huat Tan
- Department of Medical Oncology, National Cancer Centre Singapore
- Bee Choo Tai
- Saw Swee Hock School of Public Health, National University of Singapore
- Ross Andrew Soo
- Cancer Science Institute of Singapore, National University of Singapore
- Wai Leong Tam
- Genome Institute of Singapore
- Bing Lim
- Genome Institute of Singapore
- DOI
- https://doi.org/10.1038/ncomms11702
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 16
Abstract
miRNAs can function either as proto-oncogenes or tumour suppressors in several cancers; however their function in tumour initiating cells is unclear. Here, Zhang et al. show that tumour initiating cell-specific miR-1246 and miR-1290 promote lung cancer initiation and metastasis and could serve as prognostic markers.
