Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly

Jurica Matković; Subhadip Ghosh; Mateja Ćosić; Susana Eibes; Marin Barišić; Nenad Pavin; Iva M. Tolić

doi:10.1038/s41467-022-34957-4

Nature Communications (Nov 2022)

Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly

Jurica Matković,
Subhadip Ghosh,
Mateja Ćosić,
Susana Eibes,
Marin Barišić,
Nenad Pavin,
Iva M. Tolić

Affiliations

Jurica Matković: Division of Molecular Biology, Ruđer Bošković Institute
Subhadip Ghosh: Department of Physics, Faculty of Science, University of Zagreb
Mateja Ćosić: Division of Molecular Biology, Ruđer Bošković Institute
Susana Eibes: Cell Division and Cytoskeleton, Danish Cancer Society Research Center
Marin Barišić: Cell Division and Cytoskeleton, Danish Cancer Society Research Center
Nenad Pavin: Department of Physics, Faculty of Science, University of Zagreb
Iva M. Tolić: Division of Molecular Biology, Ruđer Bošković Institute

DOI: https://doi.org/10.1038/s41467-022-34957-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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Mitotic spindle assembly is not fully understood. This work reveals that kinetochores drive the coarsening of a uniform microtubule array into bundles, which promote spindle formation and chromosome segregation fidelity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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