Clinical Epidemiology (Nov 2021)
High Validity of the Danish National Patient Registry for Systemic Anticancer Treatment Registration from 2009 to 2019
Abstract
Charles Vesteghem,1– 3 Rasmus Froberg Brøndum,1– 3 Ursula G Falkmer,1,3,4 Anton Pottegård,5 Laurids Østergaard Poulsen,1,3,4 Martin Bøgsted1– 3 1Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; 2Department of Hematology, Aalborg University Hospital, Aalborg, Denmark; 3Clinical Cancer Research Centre, Aalborg University Hospital, Aalborg, Denmark; 4Department of Oncology, Aalborg University Hospital, Aalborg, Denmark; 5Department of Public Health, University of Southern Denmark, Odense, DenmarkCorrespondence: Charles VesteghemDepartment of Clinical Medicine, Aalborg University, Søndre Skovvej 15, Aalborg, 9000, DenmarkTel +45 97 66 38 72Fax +45 97 66 63 23Email [email protected]: The Danish National Patient Registry is a major resource for Danish epidemiology. Only a few studies have been conducted to check the validity of the reporting of systemic anticancer treatments. In this study, we assessed this validity for a range of cancer types over a long period of time.Patients and Methods: We extracted systemic anticancer treatment procedures from the Danish National Patient Registry for patients with solid malignant tumors treated at the Department of Oncology at Aalborg University Hospital between 2009 and 2019 (12,014 patients with 215,293 drug records). These data were compared to records obtained from the antineoplastic prescription database used at the department. We estimated the sensitivity, positive predictive value (PPV), and F1-score defined as the harmonic mean of the sensitivity and the PPV.Results: There was an overall high concordance between the two datasets with a sensitivity and a PPV > 92%. Treatments for brain, ovarian and endometrial cancers displayed lower concordance (81– 89%). The validity was stable over the study period, with a slight drop during 2016– 2017. Most drugs had a high validity with F1-scores above 90%. Fluorouracil, gemcitabine, pemetrexed, pembrolizumab, and nivolumab had F1-scores above 97%. Drugs that were introduced in the study period, such as lapatinib, palbociclib, erlotinib, pertuzumab, and panitumumab, yielded lower F1-scores due to the absence of specific registry codes early after introduction.Conclusion: The Danish National Patient Registry can be used to reliably obtain information about systemic anticancer treatments, keeping in mind limitations for recently introduced drugs and for some types of cancer.Keywords: antineoplastic agents, registries, Danish National Patient Registry, epidemiology, sensitivity and specificity, validity
