SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence

Yoshikazu Johmura; Jia Sun; Kyoko Kitagawa; Keiko Nakanishi; Toshiya Kuno; Aya Naiki-Ito; Yumi Sawada; Tomomi Miyamoto; Atsushi Okabe; Hiroyuki Aburatani; ShengFan Li; Ichiro Miyoshi; Satoru Takahashi; Masatoshi Kitagawa; Makoto Nakanishi

doi:10.1038/ncomms10574

Nature Communications (Feb 2016)

SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence

Yoshikazu Johmura,
Jia Sun,
Kyoko Kitagawa,
Keiko Nakanishi,
Toshiya Kuno,
Aya Naiki-Ito,
Yumi Sawada,
Tomomi Miyamoto,
Atsushi Okabe,
Hiroyuki Aburatani,
ShengFan Li,
Ichiro Miyoshi,
Satoru Takahashi,
Masatoshi Kitagawa,
Makoto Nakanishi

Affiliations

Yoshikazu Johmura: Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University
Jia Sun: Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University
Kyoko Kitagawa: Department of Molecular Biology, Hamamatsu University School of Medicine, Higashi-ku
Keiko Nakanishi: Department of Perinatology, Aichi Human Service Center, Institute for Developmental Research
Toshiya Kuno: Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya City University
Aya Naiki-Ito: Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya City University
Yumi Sawada: Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University
Tomomi Miyamoto: Department of Comparative and Experimental Medicine and Center for Animal Sciences, Graduate School of Medical Sciences, Nagoya City University
Atsushi Okabe: Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo
Hiroyuki Aburatani: Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo
ShengFan Li: Zhongshan Hospital of Dalian University
Ichiro Miyoshi: Department of Comparative and Experimental Medicine and Center for Animal Sciences, Graduate School of Medical Sciences, Nagoya City University
Satoru Takahashi: Department of Experimental Pathology and Tumor Biology, Graduate School of Medical Sciences, Nagoya City University
Masatoshi Kitagawa: Department of Molecular Biology, Hamamatsu University School of Medicine, Higashi-ku
Makoto Nakanishi: Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University

DOI: https://doi.org/10.1038/ncomms10574
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Cellular senescence—the permanent cessation of cell proliferation—is a process that can be deregulated in cancer and other aging-related diseases. Here the authors demonstrate that the SCFFbxo22-KDM4A complex plays an essential role during senescence as an E3 ligase that targets methylated p53 for degradation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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