Nature Communications (Jan 2016)

A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium

  • Ksenija Slavic,
  • Sanjeev Krishna,
  • Aparajita Lahree,
  • Guillaume Bouyer,
  • Kirsten K. Hanson,
  • Iset Vera,
  • Jon K. Pittman,
  • Henry M. Staines,
  • Maria M. Mota

DOI
https://doi.org/10.1038/ncomms10403
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

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Iron is an essential nutrient but, in high concentrations, it is also toxic to cells. Here, Slavic et al. identify an iron transporter in malaria parasites that plays a major role in iron detoxification and is required for the parasite’s normal development.