Superparamagnetic Iron Oxide Nanoparticles and Static Magnetic Field Regulate Neural Stem Cell Proliferation

Dan Li; Dan Li; Dan Li; Yangnan Hu; Yangnan Hu; Hao Wei; Wei Chen; Wei Chen; Yun Liu; Yun Liu; Xiaoqian Yan; Xiaoqian Yan; Lingna Guo; Lingna Guo; Lingna Guo; Menghui Liao; Menghui Liao; Bo Chen; Renjie Chai; Renjie Chai; Mingliang Tang; Mingliang Tang

doi:10.3389/fncel.2021.815280

Frontiers in Cellular Neuroscience (Feb 2022)

Superparamagnetic Iron Oxide Nanoparticles and Static Magnetic Field Regulate Neural Stem Cell Proliferation

Dan Li,
Dan Li,
Dan Li,
Yangnan Hu,
Yangnan Hu,
Hao Wei,
Wei Chen,
Wei Chen,
Yun Liu,
Yun Liu,
Xiaoqian Yan,
Xiaoqian Yan,
Lingna Guo,
Lingna Guo,
Lingna Guo,
Menghui Liao,
Menghui Liao,
Bo Chen,
Renjie Chai,
Renjie Chai,
Mingliang Tang,
Mingliang Tang

Affiliations

Dan Li: School of Biology, Food and Environment, Hefei University, Hefei, China
Dan Li: Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China
Dan Li: School of Life Sciences and Technology, Southeast University, Nanjing, China
Yangnan Hu: Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China
Yangnan Hu: School of Life Sciences and Technology, Southeast University, Nanjing, China
Hao Wei: Department of Otorhinolaryngology Head and Neck Surgery, Drum Tower Clinical Medical College, Nanjing Medical University, Nanjing, China
Wei Chen: Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China
Wei Chen: School of Life Sciences and Technology, Southeast University, Nanjing, China
Yun Liu: Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China
Yun Liu: School of Life Sciences and Technology, Southeast University, Nanjing, China
Xiaoqian Yan: Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China
Xiaoqian Yan: School of Life Sciences and Technology, Southeast University, Nanjing, China
Lingna Guo: Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China
Lingna Guo: School of Life Sciences and Technology, Southeast University, Nanjing, China
Lingna Guo: Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
Menghui Liao: Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China
Menghui Liao: School of Life Sciences and Technology, Southeast University, Nanjing, China
Bo Chen: Materials Science and Devices Institute, Suzhou University of Science and Technology, Suzhou, China
Renjie Chai: Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China
Renjie Chai: School of Life Sciences and Technology, Southeast University, Nanjing, China
Mingliang Tang: Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China
Mingliang Tang: Department of Cardiovascular Surgery of the First Affiliated Hospital and Institute for Cardiovascular Science, Medical College, Soochow University, Suzhou, China

DOI: https://doi.org/10.3389/fncel.2021.815280
Journal volume & issue: Vol. 15

Abstract

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Neural stem cells (NSCs) transplantation is a promising approach for the treatment of various neurodegenerative diseases. Superparamagnetic iron oxide nanoparticles (SPIOs) are reported to modulate stem cell behaviors and are used for medical imaging. However, the detailed effects of SPIOs under the presence of static magnetic field (SMF) on NSCs are not well elucidated. In this study, it was found that SPIOs could enter the cells within 24 h, while they were mainly distributed in the lysosomes. SPIO exhibited good adhesion and excellent biocompatibility at concentrations below 500 μg/ml. In addition, SPIOs were able to promote NSC proliferation in the absence of SMF. In contrast, the high intensity of SMF (145 ± 10 mT) inhibited the expansion ability of NSCs. Our results demonstrate that SPIOs with SMF could promote NSC proliferation, which could have profound significance for tissue engineering and regenerative medicine for SPIO applications.

Published in Frontiers in Cellular Neuroscience

ISSN: 1662-5102 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/cellular-neuroscience

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