Microstructural mapping of dentate gyrus pathology in Alzheimer’s disease: A 16.4 Tesla MRI study

Nien-Chu Shih; Nyoman D. Kurniawan; Ryan P. Cabeen; Laura Korobkova; Ellen Wong; Helena C Chui; Kristi A. Clark; Carol A Miller; Debra Hawes; Kymry T. Jones; Farshid Sepehrband

NeuroImage: Clinical (Jan 2023)

Microstructural mapping of dentate gyrus pathology in Alzheimer’s disease: A 16.4 Tesla MRI study

Nien-Chu Shih,
Nyoman D. Kurniawan,
Ryan P. Cabeen,
Laura Korobkova,
Ellen Wong,
Helena C Chui,
Kristi A. Clark,
Carol A Miller,
Debra Hawes,
Kymry T. Jones,
Farshid Sepehrband

Affiliations

Nien-Chu Shih: USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Nyoman D. Kurniawan: Center for Advanced Imaging, The University of Queensland, Brisbane 4072, Australia
Ryan P. Cabeen: USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Laura Korobkova: Neuroscience Graduate Program, University of Southern California, Los Angeles, CA 90089. USA
Ellen Wong: Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242, USA
Helena C Chui: Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Kristi A. Clark: Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Carol A Miller: Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Debra Hawes: Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Department of Pathology and Laboratory Medicine, Children’s Hospital of Los Angeles, Los Angeles, CA 90033, USA
Kymry T. Jones: Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Corresponding authors at: at: Department of Pathology, Keck School of Medicine, USC, 2011 Zonal Ave. Los Angeles, CA 90033, USA (K.T. Jones). USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, USC, 2025 Zonal Ave. Los Angeles, CA 90033, USA (F. Sepehrband).
Farshid Sepehrband: USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; Corresponding authors at: at: Department of Pathology, Keck School of Medicine, USC, 2011 Zonal Ave. Los Angeles, CA 90033, USA (K.T. Jones). USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, USC, 2025 Zonal Ave. Los Angeles, CA 90033, USA (F. Sepehrband).

Journal volume & issue: Vol. 37
p. 103318

Abstract

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The dentate gyrus (DG) is an integral portion of the hippocampal formation, and it is composed of three layers. Quantitative magnetic resonance (MR) imaging has the capability to map brain tissue microstructural properties which can be exploited to investigate neurodegeneration in Alzheimer’s disease (AD). However, assessing subtle pathological changes within layers requires high resolution imaging and histological validation. In this study, we utilized a 16.4 Tesla scanner to acquire ex vivo multi-parameter quantitative MRI measures in human specimens across the layers of the DG. Using quantitative diffusion tensor imaging (DTI) and multi-parameter MR measurements acquired from AD (N = 4) and cognitively normal control (N = 6) tissues, we performed correlation analyses with histological measurements. Here, we found that quantitative MRI measures were significantly correlated with neurofilament and phosphorylated Tau density, suggesting sensitivity to layer-specific changes in the DG of AD tissues.

Published in NeuroImage: Clinical

ISSN: 2213-1582 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/neuroimage-clinical/

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