Immature excitatory neurons develop during adolescence in the human amygdala

Shawn F. Sorrells; Mercedes F. Paredes; Dmitry Velmeshev; Vicente Herranz-Pérez; Kadellyn Sandoval; Simone Mayer; Edward F. Chang; Ricardo Insausti; Arnold R. Kriegstein; John L. Rubenstein; Jose Manuel Garcia-Verdugo; Eric J. Huang; Arturo Alvarez-Buylla

doi:10.1038/s41467-019-10765-1

Nature Communications (Jun 2019)

Immature excitatory neurons develop during adolescence in the human amygdala

Shawn F. Sorrells,
Mercedes F. Paredes,
Dmitry Velmeshev,
Vicente Herranz-Pérez,
Kadellyn Sandoval,
Simone Mayer,
Edward F. Chang,
Ricardo Insausti,
Arnold R. Kriegstein,
John L. Rubenstein,
Jose Manuel Garcia-Verdugo,
Eric J. Huang,
Arturo Alvarez-Buylla

Affiliations

Shawn F. Sorrells: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco
Mercedes F. Paredes: Department of Neurology, University of California, San Francisco
Dmitry Velmeshev: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco
Vicente Herranz-Pérez: Laboratory of Comparative Neurobiology, Institute Cavanilles, University of Valencia, CIBERNED
Kadellyn Sandoval: Department of Neurology, University of California, San Francisco
Simone Mayer: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco
Edward F. Chang: Department of Neurological Surgery, University of California, San Francisco
Ricardo Insausti: Human Neuroanatomy Laboratory, School of Medicine and CRIB, University of Castilla-La Mancha
Arnold R. Kriegstein: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco
John L. Rubenstein: Department of Psychiatry, Rock Hall, University of California, San Francisco
Jose Manuel Garcia-Verdugo: Laboratory of Comparative Neurobiology, Institute Cavanilles, University of Valencia, CIBERNED
Eric J. Huang: Department of Pathology, University of California, San Francisco
Arturo Alvarez-Buylla: Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco

DOI: https://doi.org/10.1038/s41467-019-10765-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Immature excitatory neurons in the human amygdala persist throughout life and could be a substrate for plasticity. Here the authors find evidence that the maturation of these cells may be accelerated during puberty.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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