ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function

Abstract

CTCF mediates DNA–DNA interactions by forming dimers that directly bind to both sides of the DNA. Here the authors reveal that a CTCF known associated zinc finger, ZNF143, mediates gene transcription through CTCF–DNA binding to maintain murine hematopoietic stem and progenitor cell integrity.