Atypical hyperplasias of the breast

Abstract

The paper describes different types of atypical hyperplasia of the breast. It analyzes numerous works dealing with the evaluation of atypical ductal and lobular hyperplasias as a risk factor for breast cancer. The similar analysis has been also carried out in a cohort of women with a family history. The current capabilities of visual, cytological, morphological, and molecular biological diagnosis of atypical hyperplasias are considered. Modern-day guidelines for the treatment policy and monitoring of treated patients are given. The role and place of different chemoprevention options for this cohort of patients are considered. Whether preventive surgery may and should be performed particularly in a cohort of women with a family history is determined.

Keywords

• атипичные гиперплазии молочной железы
• протоковая гиперплазия
• дольковая гиперплазия
• рак молочной железы
• высокомолекулярные цитокератины
• иммуногистохимия
• е-кадгерин
• профилактическая мастэктомия
• химиопрофилактика