Nature Communications (Mar 2022)
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD
- Gizem Günes Günsel,
- Thomas M. Conlon,
- Aicha Jeridi,
- Rinho Kim,
- Zeynep Ertüz,
- Niklas J. Lang,
- Meshal Ansari,
- Mariia Novikova,
- Dongsheng Jiang,
- Maximilian Strunz,
- Mariia Gaianova,
- Christine Hollauer,
- Christina Gabriel,
- Ilias Angelidis,
- Sebastian Doll,
- Jeanine C. Pestoni,
- Stephanie L. Edelmann,
- Marlene Sophia Kohlhepp,
- Adrien Guillot,
- Kevin Bassler,
- Hannelore P. Van Eeckhoutte,
- Özgecan Kayalar,
- Nur Konyalilar,
- Tamara Kanashova,
- Sophie Rodius,
- Carolina Ballester-López,
- Carlos M. Genes Robles,
- Natalia Smirnova,
- Markus Rehberg,
- Charu Agarwal,
- Ioanna Krikki,
- Benoit Piavaux,
- Stijn E. Verleden,
- Bart Vanaudenaerde,
- Melanie Königshoff,
- Gunnar Dittmar,
- Ken R. Bracke,
- Joachim L. Schultze,
- Henrik Watz,
- Oliver Eickelberg,
- Tobias Stoeger,
- Gerald Burgstaller,
- Frank Tacke,
- Vigo Heissmeyer,
- Yuval Rinkevich,
- Hasan Bayram,
- Herbert B. Schiller,
- Marcus Conrad,
- Robert Schneider,
- Ali Önder Yildirim
Affiliations
- Gizem Günes Günsel
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Thomas M. Conlon
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Aicha Jeridi
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Rinho Kim
- Institute of Functional Epigenetics, Helmholtz Munich
- Zeynep Ertüz
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Niklas J. Lang
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Meshal Ansari
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Mariia Novikova
- Institute of Metabolism and Cell Death, Helmholtz Munich
- Dongsheng Jiang
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Maximilian Strunz
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Mariia Gaianova
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Christine Hollauer
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Christina Gabriel
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Ilias Angelidis
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Sebastian Doll
- Institute of Computational Biology, Helmholtz Munich
- Jeanine C. Pestoni
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Stephanie L. Edelmann
- Research Unit Molecular Immune Regulation, Helmholtz Munich
- Marlene Sophia Kohlhepp
- Department of Hepatology & Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM)
- Adrien Guillot
- Department of Hepatology & Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM)
- Kevin Bassler
- Department for Genomics & Immunoregulation, LIMES-Institute, University of Bonn
- Hannelore P. Van Eeckhoutte
- Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University, University Hospital Ghent
- Özgecan Kayalar
- Koç University Research Center for Translational Medicine (KUTTAM)
- Nur Konyalilar
- Koç University Research Center for Translational Medicine (KUTTAM)
- Tamara Kanashova
- Max-Delbrück Center for Molecular Medicine
- Sophie Rodius
- Proteomics of cellular signalling, Luxembourg Institute of Health
- Carolina Ballester-López
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Carlos M. Genes Robles
- Institute of Functional Epigenetics, Helmholtz Munich
- Natalia Smirnova
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Markus Rehberg
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Charu Agarwal
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Ioanna Krikki
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Benoit Piavaux
- Czech Centre for Phenogenomics, Institute of Molecular Genetics of the Czech Academy of Sciences
- Stijn E. Verleden
- Division of Pneumology, KU Leuven
- Bart Vanaudenaerde
- Division of Pneumology, KU Leuven
- Melanie Königshoff
- Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh
- Gunnar Dittmar
- Proteomics of cellular signalling, Luxembourg Institute of Health
- Ken R. Bracke
- Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University, University Hospital Ghent
- Joachim L. Schultze
- Department for Genomics & Immunoregulation, LIMES-Institute, University of Bonn
- Henrik Watz
- Pulmonary Research Institute at LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL)
- Oliver Eickelberg
- Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh
- Tobias Stoeger
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Gerald Burgstaller
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Frank Tacke
- Department of Hepatology & Gastroenterology, Charité - Universitätsmedizin Berlin, Campus Virchow-Klinikum (CVK) and Campus Charité Mitte (CCM)
- Vigo Heissmeyer
- Research Unit Molecular Immune Regulation, Helmholtz Munich
- Yuval Rinkevich
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Hasan Bayram
- Koç University Research Center for Translational Medicine (KUTTAM)
- Herbert B. Schiller
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- Marcus Conrad
- Institute of Metabolism and Cell Death, Helmholtz Munich
- Robert Schneider
- Institute of Functional Epigenetics, Helmholtz Munich
- Ali Önder Yildirim
- Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL)
- DOI
- https://doi.org/10.1038/s41467-022-28809-4
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
Chronic obstructive pulmonary disease is a progressive and incurable chronic condition that involves accumulation of inflammatory macrophages in the lung tissue. Authors here show in mouse models of lung disease that PRMT7, a protein arginine methyltransferase, is an important regulator of recruitment and the pro-inflammatory phenotype of macrophages.
