COMPARATIVE EVALUATION OF THE EFFICACY OF AMINOCAPROIC AND TRANEXAMIC ACIDS DURING HEART SURGERY

Abstract

Objectives. To perform a comparative analysis of the efficacy of aminocaproic (EACA) and tranexamic acid (TX) for heart surgery with cardiopulmonary bypass (CPB). Material and methods. Three groups were formed: group 1 (n = 50) –EACA bolus was used (75 mg/kg) with titration of 30 mg/kg/h during CPB; group 2 (n = 30) – TX bolus was injected (12.5 mg/kg) with titration of 6.5 mg/ kg/h during the CPB and 1 mg/kg/h during the first 6 hours after surgery; group 3 (n = 60) – the controls. Results. The volume of perioperative blood loss in the first 42–48 hours in group 1 was 20.4 (16.4; 25.2) ml/kg, in group 2 – 19.3 (13.8; 22.4) ml/kg, in group 3 – 22.8 (19.0; 28.3) ml/kg. The frequency of transfusions was 8%, 3% and 28% respectively. Conclusion. The administration of EACA (10.1 (8.4; 11.5) g) or TX (2.5 (2.1; 3.0) g) effectively reduces perioperative blood loss and lowers the frequency of transfusions within 42-48 hours after CPB surgery, without increasing the number of complications and mortality.

Keywords

• aminocaproic acid
• tranexamic acid
• cardiac surgery
• cardiopulmonary bypass
• blood loss
• blood products