Life (May 2020)

Health-Related Quality of Life and Frailty in Chronic Liver Diseases

  • Hiroki Nishikawa,
  • Kazunori Yoh,
  • Hirayuki Enomoto,
  • Yoshinori Iwata,
  • Yoshiyuki Sakai,
  • Kyohei Kishino,
  • Yoshihiro Shimono,
  • Naoto Ikeda,
  • Tomoyuki Takashima,
  • Nobuhiro Aizawa,
  • Ryo Takata,
  • Kunihiro Hasegawa,
  • Takashi Koriyama,
  • Yukihisa Yuri,
  • Takashi Nishimura,
  • Shuhei Nishiguchi,
  • Hiroko Iijima

DOI
https://doi.org/10.3390/life10050076
Journal volume & issue
Vol. 10, no. 5
p. 76

Abstract

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We sought to examine the relationship between frailty and health-related quality of life as evaluated using the 36-item Short-Form Health Survey (SF-36) questionnaire in Japanese chronic liver disease (CLD) patients (n = 341, 122 liver cirrhosis cases, median age = 66 years). Frailty was defined as a clinical syndrome in which three or more of the following criteria were met (frailty score 3, 4, or 5): unintentional body weight loss, self-reported exhaustion, muscle weakness (grip strength: p p = 0.0126), physical functioning (p = 0.0005), and vitality (p = 0.0246) were independent predictors linked to the presence of frailty. In conclusion, Japanese CLD patients with frailty displayed poorer conditions, both physically and mentally.

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