Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour

Candela Sánchez-Bellot; Rawan AlSubaie; Karyna Mishchanchuk; Ryan W. S. Wee; Andrew F. MacAskill

doi:10.1038/s41467-022-27977-7

Nature Communications (Jan 2022)

Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour

Candela Sánchez-Bellot,
Rawan AlSubaie,
Karyna Mishchanchuk,
Ryan W. S. Wee,
Andrew F. MacAskill

Affiliations

Candela Sánchez-Bellot: Department of Neuroscience, Physiology and Pharmacology, University College London, Gower St
Rawan AlSubaie: Department of Neuroscience, Physiology and Pharmacology, University College London, Gower St
Karyna Mishchanchuk: Department of Neuroscience, Physiology and Pharmacology, University College London, Gower St
Ryan W. S. Wee: Department of Neuroscience, Physiology and Pharmacology, University College London, Gower St
Andrew F. MacAskill: Department of Neuroscience, Physiology and Pharmacology, University College London, Gower St

DOI: https://doi.org/10.1038/s41467-022-27977-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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The authors reveal a mechanism for regulation of behaviour during approach avoidance conflicts that relies on two specialized, parallel circuits that allow bidirectional hippocampal control of the prefrontal cortex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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