Nature Communications (Nov 2022)
The inner junction protein CFAP20 functions in motile and non-motile cilia and is critical for vision
- Paul W. Chrystal,
- Nils J. Lambacher,
- Lance P. Doucette,
- James Bellingham,
- Elena R. Schiff,
- Nicole C. L. Noel,
- Chunmei Li,
- Sofia Tsiropoulou,
- Geoffrey A. Casey,
- Yi Zhai,
- Nathan J. Nadolski,
- Mohammed H. Majumder,
- Julia Tagoe,
- Fabiana D’Esposito,
- Maria Francesca Cordeiro,
- Susan Downes,
- Jill Clayton-Smith,
- Jamie Ellingford,
- Genomics England Research Consortium,
- Omar A. Mahroo,
- Jennifer C. Hocking,
- Michael E. Cheetham,
- Andrew R. Webster,
- Gert Jansen,
- Oliver E. Blacque,
- W. Ted Allison,
- Ping Yee Billie Au,
- Ian M. MacDonald,
- Gavin Arno,
- Michel R. Leroux
Affiliations
- Paul W. Chrystal
- Department of Biological Sciences, University of Alberta
- Nils J. Lambacher
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Lance P. Doucette
- Department of Ophthalmology & Visual Science, University of Alberta
- James Bellingham
- UCL Institute of Ophthalmology
- Elena R. Schiff
- Moorfields Eye Hospital
- Nicole C. L. Noel
- Department of Medical Genetics, University of Alberta
- Chunmei Li
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Sofia Tsiropoulou
- School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield
- Geoffrey A. Casey
- Department of Medical Genetics, University of Alberta
- Yi Zhai
- Department of Ophthalmology & Visual Science, University of Alberta
- Nathan J. Nadolski
- Division of Anatomy, Department of Surgery, University of Alberta
- Mohammed H. Majumder
- Department of Biological Sciences, University of Alberta
- Julia Tagoe
- Lethbridge Outreach Genetics Service, Alberta Health Services
- Fabiana D’Esposito
- Western Eye Hospital, Imperial College Healthcare NHS Trust
- Maria Francesca Cordeiro
- ICORG, Imperial College London
- Susan Downes
- Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust
- Jill Clayton-Smith
- Manchester Centre for Genomic Medicine, Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Jamie Ellingford
- Manchester Centre for Genomic Medicine, Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester
- Genomics England Research Consortium
- Omar A. Mahroo
- UCL Institute of Ophthalmology
- Jennifer C. Hocking
- Department of Medical Genetics, University of Alberta
- Michael E. Cheetham
- UCL Institute of Ophthalmology
- Andrew R. Webster
- UCL Institute of Ophthalmology
- Gert Jansen
- Department of Cell Biology, Erasmus University Medical Centre
- Oliver E. Blacque
- School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield
- W. Ted Allison
- Department of Biological Sciences, University of Alberta
- Ping Yee Billie Au
- Department of Medical Genetics, Alberta Children’s Hospital Research Institute, Cumming School of Medicine, University of Calgary
- Ian M. MacDonald
- Department of Medical Genetics, University of Alberta
- Gavin Arno
- UCL Institute of Ophthalmology
- Michel R. Leroux
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- DOI
- https://doi.org/10.1038/s41467-022-33820-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 22
Abstract
Motile and non-motile cilia have distinct functions and protein complexes associated with them. Here, the authors show the conserved protein CFAP20 is important for both motile and non-motile cilia and is distinct from other ciliopathy-associated domains or macromolecular complexes.
