Nature Communications (Nov 2019)

Synergy between Cyclase-associated protein and Cofilin accelerates actin filament depolymerization by two orders of magnitude

  • Shashank Shekhar,
  • Johnson Chung,
  • Jane Kondev,
  • Jeff Gelles,
  • Bruce L. Goode

DOI
https://doi.org/10.1038/s41467-019-13268-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Cellular actin networks can be rapidly disassembled and remodeled in a few seconds, yet in vitro actin filaments depolymerize over minutes. Here the authors show that Cyclase-associated protein (CAP) and Cofilin synergize to processively depolymerize actin filament pointed ends 330-fold faster than spontaneous depolymerization.