Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside

Ruilong Zhao; Haiyan Lin; Lara Bereza-Malcolm; Elizabeth Clarke; Christopher John Jackson; Meilang Xue

doi:10.3390/ijms20040903

International Journal of Molecular Sciences (Feb 2019)

Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside

Ruilong Zhao,
Haiyan Lin,
Lara Bereza-Malcolm,
Elizabeth Clarke,
Christopher John Jackson,
Meilang Xue

Affiliations

Ruilong Zhao: Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Northern Clinical School, University of Sydney, Sydney, NSW 2065, Australia
Haiyan Lin: Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Northern Clinical School, University of Sydney, Sydney, NSW 2065, Australia
Lara Bereza-Malcolm: Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Northern Clinical School, University of Sydney, Sydney, NSW 2065, Australia
Elizabeth Clarke: Murray Maxwell Biomechanics Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Northern Clinical School, University of Sydney, Sydney, NSW 2065, Australia
Christopher John Jackson: Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Northern Clinical School, University of Sydney, Sydney, NSW 2065, Australia
Meilang Xue: Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Northern Clinical School, University of Sydney, Sydney, NSW 2065, Australia

DOI: https://doi.org/10.3390/ijms20040903
Journal volume & issue: Vol. 20, no. 4
p. 903

Abstract

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Independent of its well-known anticoagulation effects, activated protein C (APC) exhibits pleiotropic cytoprotective properties. These include anti-inflammatory actions, anti-apoptosis, and endothelial and epithelial barrier stabilisation. Such beneficial effects have made APC an attractive target of research in a plethora of physiological and pathophysiological processes. Of note, the past decade or so has seen the emergence of its roles in cutaneous wound healing—a complex process involving inflammation, proliferation and remodelling. This review will highlight APC’s functions and mechanisms, and detail its pre-clinical and clinical studies on cutaneous wound healing.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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